Noticia de Carlos Gimbernat y de sus mapas geológicos de Europa Central, Alpes, Francia e Italia a principios del siglo XIX

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Encoding process discovery problems in SMT

Information systems, which are responsible for driving many processes in our lives (health care, the web, municipalities, commerce and business, among others), store information in the form of logs which is often left unused. Process mining, a discipline in between data mining and software engineering, proposes tailored algorithms to exploit the information stored in a log, in order to reason about the processes underlying an information system. A key challenge in process mining is discovery: Given a log, derive a formal process model that can be used afterward for a formal analysis. In this paper, we provide a general approach based on satisfiability modulo theories (SMT) as a solution for this challenging problem. By encoding the problem into the logical/arithmetic domains and using modern SMT engines, it is shown how two separate families of process models can be discovered. The theory of this paper is accompanied with a tool, and experimental results witness the significance of this novel view of the process discovery problem.Peer ReviewedPostprint (author's final draft

Measuring Receiver Benchmark for Conducted and Radiated Emissions Testing in Space Applications

This paper compares the measurement results obtained from three different implementations of measuring receivers regarding spectral level accuracy. The objective is to validate the suitability of direct sampling electromagnetic emissions measurements with respect to those delivered by a high-end EMI receiver in frequency swept and FFT modes. The experimental setups follow the verification methods described in the ECSS-E-ST-20-07C Rev.2 standard to set realistic and reproducible conditions. Between 50 kHz and 100 MHz, common mode and differential mode currents are measured when multisine excitation signals with controlled amplitude profiles are used as references. Subsequently, conducted and radiated emissions tests are run to investigate the correlation between measurements with the different receivers. The instruments used are a low-cost USB digitiser Picoscope PS5444D, a high-performance benchtop oscilloscope R&S RTO6 and the R&S ESW44 full-compliant EMI test receiver. The analysis concludes that the emissions measurements performed with the direct sampling approach are excellent for the intended application, exhibiting an accuracy comparable to the dedicated EMI test receiver and a well adequate dynamic range and noise level.The project (21NRM06 EMC-STD) has received funding from the European Partnership on Metrology, co-financed by the European Union's Horizon Europe Research and Innovation Programme and by the Participating States. EMC Barcelona's project under grant number SNEO-20211223 has received funding from CDTI, which is supported by "Ministerio de Ciencia e Innovación" and financed by the European Union - NextGenerationEU - through the guidelines included in the `Plan de Recuperación, Transformación y Resiliencia". Dr. Azpúrua has received funding from the StandICT.eu 2023 project, financed by the European Union's Horizon Europe - Research and Innovation Programme - under grant agreement No. 951972. Dr. Pous' work was supported in part by the European Union's Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No. 801342 (TecniospringINDUSTRY) and the Government of Catalonia's Agency for Business Competitiveness (ACCIÓ) and in part by the Spanish "Ministerio de Ciencia e Innovaci´on" under project PID2019-106120RBC31/AEI/10.13039/501100011033

Placental weight centiles adjusted for age, parity and fetal sex

Introduction The weight of the placenta can be indicative of efficacy in nutrient and oxygen supply. Furthermore, it has been suggested that a measure of the placenta's ability to adequately supply nutrients to the fetus can be found in the relationship between birth weight and placental weight expressed as a ratio. Our aim was to develop age adjusted placenta weight and birth weight to placenta weight ratio reference curves that are stratified by maternal parity and fetal sex. Methods We included singleton, non-anomalous births with a gestational age inclusive of 28 + 0 weeks to 42 + 6 weeks. Excluded were pregnancies of multiplicity, fetuses with congenital abnormalities, stillbirths and pregnancies that had placental complications (ie placenta previa or abruption). Generalised additive model for location, shape and scale (GAMLSS) was used to fit reference curves. Results We stratified 97,882 pregnancies by maternal nulliparity status and fetal sex. Extensive assessment model goodness-of-fit showed appropriate modeling and accurate fit to the four parameters of distribution. Our results show accurate model fit of the reference curves to the data. We demonstrated that the influence that parity has on the placenta weight is far greater than that exerted by fetal sex, and that the difference is dependent on gestational age. Discussion This is the largest presentation of age and parity adjusted placenta weight and feto-placental weight ratio reference ranges to date. The difference observed between nulliparous and multiparous pregnancies could be explained by biological memory and the remnants of maternal endo-myometrial vascularity after the first pregnancy.publishedVersio

Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18

Haematopoietic malignancies are frequently characterized by karyotypic abnormalities. The development of targeted drugs has been pioneered with compounds against gene products of fusion genes caused by chromosomal translocations. While polysomies are equally frequent as translocations, for many of them we are lacking therapeutic approaches aimed at synthetic lethality. Here, we report two new cell lines, named MBU-7 and MBU-8, that differ in complete trisomy of chromosome18, a partial trisomy of chromosome 7 and a tetrasomy of the p-arm of chromosome 8, but otherwise share the same mutational pattern and complex karyotype. Both cell lines are divergent clones of U-937 cells and have the morphology and immunoprofile of monocytic cells. The distinct karyotypic differences between MBU-7 and MBU-8 are associated with a difference in the specific response to nucleoside analogues. Taken together, we propose the MBU-7 and MBU-8 cell lines described here as suitable in vitro models for screening and testing vulnerabilities that are associated with the disease-relevant polysomies of chromosome 7, 8 and 18

Knowledge-defined networking

The research community has considered in the past the application of Artificial Intelligence (AI) techniques to control and operate networks. A notable example is the Knowledge Plane proposed by D.Clark et al. However, such techniques have not been extensively prototyped or deployed in the field yet. In this paper, we explore the reasons for the lack of adoption and posit that the rise of two recent paradigms: Software-Defined Networking (SDN) and Network Analytics (NA), will facilitate the adoption of AI techniques in the context of network operation and control. We describe a new paradigm that accommodates and exploits SDN, NA and AI, and provide use-cases that illustrate its applicability and benefits. We also present simple experimental results that support, for some relevant use-cases, its feasibility. We refer to this new paradigm as Knowledge-Defined Networking (KDN).Peer ReviewedPostprint (author's final draft

Connecting Peptide Physicochemical and Antimicrobial Properties by a Rational Prediction Model

The increasing rate in antibiotic-resistant bacterial strains has become an imperative health issue. Thus, pharmaceutical industries have focussed their efforts to find new potent, non-toxic compounds to treat bacterial infections. Antimicrobial peptides (AMPs) are promising candidates in the fight against antibiotic-resistant pathogens due to their low toxicity, broad range of activity and unspecific mechanism of action. In this context, bioinformatics' strategies can inspire the design of new peptide leads with enhanced activity. Here, we describe an artificial neural network approach, based on the AMP's physicochemical characteristics, that is able not only to identify active peptides but also to assess its antimicrobial potency. The physicochemical properties considered are directly derived from the peptide sequence and comprise a complete set of parameters that accurately describe AMPs. Most interesting, the results obtained dovetail with a model for the AMP's mechanism of action that takes into account new concepts such as peptide aggregation. Moreover, this classification system displays high accuracy and is well correlated with the experimentally reported data. All together, these results suggest that the physicochemical properties of AMPs determine its action. In addition, we conclude that sequence derived parameters are enough to characterize antimicrobial peptides

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth

Genome-wide association study of placental weight in 65,405 newborns and 113,620 parents reveals distinct and shared genetic influences between placental and fetal growth

A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth

ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.Peer reviewe